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No landline or engineer visit. Two groups of cells, located at the dorsal and ventral midlines and known as the roof plate and the floor plate, respectively, appear to act as sources of cues for commissural axons.
The roof plate appears to direct initial axon extension away from the dorsal midline through the release of a diffusible chemorepellent, whereas the floor plate provides both contact-mediated and diffusible cues for commissural axon navigation towards and across the midline.
We are currently trying to determine how roof plate- and floor plate-derived signals act to influence the direction of growth of commissural axons.
The ventral midline of the neural tube consists of several subgroups of cells that differ, according to their position in the rostro-caudal axis, in the expression of cellular markers and signaling molecules.
Throughout the axis, these cells appear to have multiple roles in the patterning of adjacent cell types and axons. To begin to study the mechanisms underlying cell identity within the neural tube we have therefore examined the development of the ventral midline cell groups.
By analyzing changes in neural cell identity and pattern within neural tube explants, we have shown that axial mesodermal cells of the notochord and prechordal mesoderm provide inductive signals that initiate the differentiation of the ventral midline and patterning of neurons within the neural plate.
Sonic hedgehog appears to mediate the induction of floor plate by notochord, but in rostral regions sonic hedgehog appears to act cooperatively with another signaling molecule to generate ventral midline cells with rostral properties.
Current experiments are directed at the molecular identification of mesoderm-derived inducing signals at different rostro-caudal levels and the characterization of the response of neuroepithelial cells to such signals.

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Enzyme und Inhibitoren. Merck Index. The process of claim I or 2, wherein the silicon halide is added in an amount to provide about 0. A film Doppelt Englisch to claim 7 wherein the photoinitiator compound is present in from 0.







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